Human antithrombin III heterogeneity
نویسندگان
چکیده
منابع مشابه
Antimicrobial antithrombin III peptide 1 Antimicrobial effects of helix D-derived peptides of human antithrombin III*
Antithrombin III (ATIII) is a key antiproteinase involved in blood coagulation. Previous investigations have shown that ATIII is degraded by Staphylococcus aureus V8 protease, leading to release of heparin binding fragments derived from its D helix. As heparin binding and antimicrobial activity of peptides frequently overlap, we here set out to explore possible antibacterial effects of intact a...
متن کاملStructural studies on the carbohydrate portion of human antithrombin III.
Human antithrombin III has been shown to contain four identical N-glycosidically linked carbohydrate chain per molecule. These carbohydrate chains have been investigated by sugar and methylation analysis before and after removal of N-acetylneuraminic acid residues. The chains have been further investigated by Smith degradation, trifluoroacetolytic degradation, and degradation after chromium tri...
متن کاملAntithrombin III Inhibits Mesangial Cell
Thrombin stimulates and heparin and heparan sulfate inhibit mesangial cell proliferation. In addition, heparin has been shown to inhibit thrombin-stimulated smooth muscle cell proliferation. The anticoagulant action of heparin is mediated by antithrombin Ill. This study investigated whether heparin’s antiproliferative action is also mediated by antithrombin Ill. To this end, the effect of antit...
متن کاملAntithrombin III during liver transplantation.
A III (AT-III) is a liver-synthesized plasma glycoprotein of moderate size (58 kD) that can inhibit most of the activated serine proteases involved in coagulation (eg. thrombin. activated factor X. VII. etc). The inactivation involves formation of an irreversible complex. probably filtered from the circulation of the RES. The complex formation is a time-dependent reaction requiring minutes for ...
متن کاملMolecular weight analysis of antithrombin III-heparin and antithrombin III-thrombin-heparin complexes.
The molecular interactions between components of the heparin-catalyzed antithrombin III/thrombin reaction were investigated by light scattering. When heparin was added to antithrombin III, the molecular weight increased to a maximum and then decreased to that of a 1:1 (antithrombin III X heparin) complex. The initial molecular weights at low heparin to antithrombin III ratios were consistent wi...
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ژورنال
عنوان ژورنال: Blood
سال: 1981
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v57.2.229.229